|
rs9970784
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis.
|
23326517 |
2013 |
|
rs9943922
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The SNPs rs9554322, rs9582036 and rs9943922 were correlated with AMD.
|
26914796 |
2016 |
|
rs9943922
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Polymorphisms in the FLT1 gene have previously been associated with neovascular AMD risk, including the rs9943922 single nucleotide polymorphism (SNP).
|
28949775 |
2018 |
|
rs9913583
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Four PEDF polymorphisms were meta-analyzed: rs1136287, rs12150053, rs12948385 and rs9913583, but none was significantly associated with AMD or PCV.
|
25820866 |
2015 |
|
rs9868689
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We observed that a recessive model was a better fit to the data for some SNPs, with associations between rs11715522 and AMD (RR, 1.27; P = .03) and between rs2669845 (RR, 3.10; P = .04), rs2853707 (RR, 0.48; P = .050), and rs9868689 (RR, 0.31; P = .02) and neovascular AMD.
|
24287500 |
2014 |
|
rs976333015
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here, we investigate the consequences of aHUS-linked mutations (R53H and R78G) within the FH N-terminal complement control protein module that also carries the I62V variation linked to dense-deposit disease and age-related macular degeneration.
|
21270465 |
2011 |
|
rs970476
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, the GATT haplotype in this gene (rs931798, rs140617, rs140616, and rs970476) is associated with lower odds of AMD (adjusted odds ratio (OR) 0.13; 95% CI 0.02⁻0.91; <i>p</i> = 0.041).
|
30257524 |
2018 |
|
rs9621532
|
|
A |
0.730 |
GeneticVariation |
GWASCAT |
Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC).
|
20385826 |
2010 |
|
rs9621532
|
|
|
0.730 |
GeneticVariation |
BEFREE |
To determine the impact of <i>HTRA1</i> rs1120638, <i>TIMP3</i> rs9621532, <i>VEGFA</i> rs833068, <i>CFI</i> rs10033900, <i>ERCC6</i> rs3793784, and <i>KCTD10</i> rs56209061 genotypes on the development of age-related macular degeneration (AMD) in the Lithuanian population.
|
31583032 |
2019 |
|
rs9621532
|
|
|
0.730 |
GeneticVariation |
BEFREE |
Polychotomous logistic regression showed a trend that rs9621532 correlates with less severe disease, for example, with the majority of carriers having intermediate AMD rather than nAMD/geographic atrophy AMD.
|
23422939 |
2013 |
|
rs9621532
|
|
A |
0.730 |
GeneticVariation |
GWASCAT |
Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration.
|
20385819 |
2010 |
|
rs9621532
|
|
|
0.730 |
GeneticVariation |
BEFREE |
Recently, two genome-wide association studies with large cohorts both identified rs9621532, a new single nucleotide polymorphism (SNP) that is associated with advanced age-related macular degeneration (AMD) and located near the TIMP3 gene.
|
22171703 |
2012 |
|
rs9621532
|
|
|
0.730 |
GeneticVariation |
GWASCAT |
Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration.
|
21665990 |
2011 |
|
rs9582036
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The SNPs rs9554322, rs9582036 and rs9943922 were correlated with AMD.
|
26914796 |
2016 |
|
rs9564692
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants.
|
26691988 |
2016 |
|
rs9554322
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The SNPs rs9554322, rs9582036 and rs9943922 were correlated with AMD.
|
26914796 |
2016 |
|
rs9554320
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The specific haplotype CA of rs9582036 and rs9554320 was associated with AMD (p = 0.035), but the correlation did not remain after correction.
|
26914796 |
2016 |
|
rs9542236
|
|
|
0.820 |
GeneticVariation |
GWASDB |
Seven new loci associated with age-related macular degeneration.
|
23455636 |
2013 |
|
rs9542236
|
|
|
0.820 |
GeneticVariation |
BEFREE |
Nineteen single nucleotide polymorphisms (SNPs) previously associated with AMD, including rs10490924 (<i>ARMS2/HTRA1</i>), rs10737680 (<i>CFH</i>), rs13278062 (<i>TNFRSF10A</i>), rs1864163 (<i>CETP</i>), rs2230199 (<i>C3</i>), rs3130783 (<i>IER3/DDR1</i>), rs334353 (<i>TGFBR1</i>), rs3812111 (<i>COL10A1</i>), rs429608 (<i>C2/CFB</i>), rs4420638 (<i>APOE</i>), rs4698775 (<i>CFI</i>), rs5749482 (<i>TIMP3</i>), rs6795735 (<i>ADAMTS9</i>), rs8017304 (<i>RAD51B</i>), rs8135665 (<i>SLC16A8</i>), rs920915 (<i>LIPC</i>), rs943080 (<i>VEGFA</i>), rs9542236 (<i>B3GALTL</i>) and rs13081855 (<i>COL8A1/FILIP1L</i>), were genotyped in this cohort.
|
31819893 |
2019 |
|
rs9542236
|
|
|
0.820 |
GeneticVariation |
BEFREE |
Rs13278062 in TNFRSF10A, rs1713985 in REST-C4ORF14-POLR2B-IGFBP7 and rs9542236 in B3GALTL were not found to be associated with AMD (all P>0.05).
|
23868022 |
2013 |
|
rs9542236
|
|
C |
0.820 |
GeneticVariation |
GWASCAT |
Seven new loci associated with age-related macular degeneration.
|
23455636 |
2013 |
|
rs953038635
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The Ala-9Ala genotype and alanine allele (Ala-9Val sequence polymorphism) is much more frequent in AMD patients than in healthy subjects.
|
20357718 |
2010 |
|
rs9513115
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The FLT1 SNPs rs9943922, rs9508034, rs2281827, rs7324510, and rs9513115 were significantly associated with increased risk of neovascular AMD.
|
24812550 |
2014 |
|
rs948987111
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Next generation sequencing (NGS) showed polymorphism in CFH (p.V62I in SCR1) and THBD (p.A473V), already known as pathogenic for C3GN, as well as a mutation in C3 (p.R102G) associated only with age-related macular degeneration (AMD) so far.
|
29592796 |
2018 |
|
rs9482193
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide analysis of disease progression in age-related macular degeneration.
|
29346644 |
2018 |